## Exclusion of subjects who are not in SS [Software]

Dear Helmut,

Adding to that, if dosing interval for reference product is 24 hours and that of test product is 12 hours i.e. tau=24 hrs. for reference and tau=12 hrs. for test product then how can we calculate AUCtau ? means if we put tau=12 hrs. for test product in the model then which AUC area will be estimated by WinNonlin i.e first 0-12 hrs or last 0-12 hrs ?

Moreover, if we calculate AUC0-24 for both test and reference in above case then how WinNonlin calculates ? Should i give common dosing interval i.e. tau=24 hrs. for both test and reference products and how much AUC0-24 calculation is reliable for test product?

Thanks and regards,

KR

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Edit: Full quote removed. Please see this post! [Ohlbe]

Adding to that, if dosing interval for reference product is 24 hours and that of test product is 12 hours i.e. tau=24 hrs. for reference and tau=12 hrs. for test product then how can we calculate AUCtau ? means if we put tau=12 hrs. for test product in the model then which AUC area will be estimated by WinNonlin i.e first 0-12 hrs or last 0-12 hrs ?

Moreover, if we calculate AUC0-24 for both test and reference in above case then how WinNonlin calculates ? Should i give common dosing interval i.e. tau=24 hrs. for both test and reference products and how much AUC0-24 calculation is reliable for test product?

Thanks and regards,

KR

--

Edit: Full quote removed. Please see this post! [Ohlbe]

### Complete thread:

- Steady state calculation using WinNonlin Imran 2007-06-27 06:02 [Software]
- Steady state calculation using WinNonlin Helmut 2007-06-27 11:56
- Steady state calculation using WinNonlin Imran 2007-06-29 05:13
- Please use the Preview! Jaime_R 2007-06-29 10:29
- Please use the Preview! Imran 2007-06-30 12:50
- no attachments and uploads... Jaime_R 2007-06-30 13:33

- Please use the Preview! Imran 2007-06-30 12:50
- Steady state calculation using WinNonlin Helmut 2007-06-29 21:08
- Steady state calculation using WinNonlin Imran 2007-08-02 13:52
- Steady state calculation using WinNonlin Helmut 2007-08-02 15:07
- Steady state calculation using WinNonlin Imran 2007-08-06 11:48
- Exclusion of subjects who are not in SS Helmut 2007-08-06 22:16
- Exclusion of subjects who are not in SSKR 2009-04-13 14:34
- Exclusion of subjects who are not in SS vixen 2020-04-27 10:10
- Common sense instead of statistics Helmut 2020-04-27 11:45

- Exclusion of subjects who are not in SS Helmut 2007-08-06 22:16

- Steady state calculation using WinNonlin Imran 2007-08-06 11:48

- Steady state calculation using WinNonlin Helmut 2007-08-02 15:07

- Steady state calculation using WinNonlin Imran 2007-08-02 13:52

- Please use the Preview! Jaime_R 2007-06-29 10:29

- Steady state calculation using WinNonlin Imran 2007-06-29 05:13

- Steady state calculation using WinNonlin Helmut 2007-06-27 11:56